ASCP ASCP Certifications ASCP-MLT Questions & Answers

• Question 501:

  Small, dense LDL is most likely to interact with arterial walls, leading to deposition of cholesterol, and initiating or worsening atherosclerosis. Small, dense LDL is associated with more than a three-fold increase in the risk of coronary heart disease.

  Large, buoyant LDL is less atherogenic than small, dense LDL. The LDL phenotype A is normal. It is the so called 'B' pattern that is associated with increased risk.

  Which of the following is most likely to interact with arterial walls, leading to deposition of cholesterol, and initiating or worsening atherosclerosis?

  A. Large buoyant LDL

  B. Small dense LDL

  C. LDL phenotype 'A'

  Correct Answer: B

• Question 502:

  Each of the drugs/drug classes listed above have been known to cause drug-induced hemolytic anemia, although cephalosporins are the MOST COMMON cause. Cephalosporins can cause drug-induced hemolytic anemia when a patient produces antibodies to the particular cephalosporin drug in the presence of red blood cells. The drugs can alter the membrane appearance of the red blood cells, causing the body to mistake them as foreign. Complement becomes activated due to these antibodies; red cells are then destroyed causing hemolytic anemia. Dark urine, caused by intravascular hemolysis, is one of the most common symptoms associated with this condition.

  Which one of the following drugs/drug classes is the MOST COMMON cause of drug- induced hemolytic anemia?

  A. Levodopa

  B. Quinidine

  C. Cephalosporins

  D. Levofloxacin

  E. Nonsteroidal anti-inflammatory drugs (NSAIDs)

  Correct Answer: C

• Question 503:

  A patient with tuberculosis would be placed in:

  A. protective isolation.

  B. body fluid isolation.

  C. droplet isolation.

  D. airborne isolation.

  Correct Answer: D

• Question 504:

  Serum calcitonin is normally produced by the C cells of the thyroid. It functions to reduce serum calcium by inhibiting release of calcium from bone. It is a peptide with a molecular weight of 3400, and has a half life of approximately 12 minutes. It is characteristically elevated in medullary carcinoma of the thyroid. Since medullary carcinoma often occurs as an autosomal disorder, family members of patients with this condition should be screened for serum calcitonin.

  Serum calcitonin is typically elevated in which of the following conditions:

  A. Medullary carcinoma of the thyroid

  B. Hyperthyroidism

  C. Glioblastoma

  D. Adrenal adenoma

  Correct Answer: A

• Question 505:

  Which of the following is NOT part of the magnification system of the microscope?

  A. arm

  B. 10 X objective lens

  C. ocular lenses-arm

  D. 4 X objective lens

  Correct Answer: A

• Question 506:

  Which of the following genotypes cause beta thalassemia minor?

  A. B/B

  B. B+/B

  C. B0/B

  D. B0/B0

  Correct Answer: B

• Question 507:

  Leptin signals the hypothalamus that there are changes in fat stores.

  Resistin increases insulin resistance and enhances adhesion molecules present on endothelial cells.

  IL-6 responds to tissue injury. IL-6 increases insulin resistance by inhibiting insulin receptor signal transduction in liver cells. It also increases other inflammatory cytokines, interleukin- 1 (IL-1) and TNF-a, and stimulates the liver to produce C-reactive protein (CRP).

  Adipose tissue and liver cells produce angiotensinogen, a precursor of angiotensin II. Besides increasing blood pressure, angiotensin II may stimulate adipose cell formation and thus increase adipose mass.

  Which one of the following adipocyte products is an important messenger in metabolism, signaling the hypothalamus that there are changes in fat stores?

  A. Leptin

  B. Resistin

  C. IL-6

  D. Angiotensinogen

  Correct Answer: A

• Question 508:

  Though it may not be required, TDM should still be used to confirm adequate dosing. Genotyping does not make TDM redundant.

  A PM will metabolize the drug more slowly and therefore will need lower doses. CYP2D6 metabolizes many different drugs; it is not associated with just one class of drugs. Anytime a drug is taken that competes for the same metabolizing enzyme as another drug, there is potential for the concentrations of both drugs to be increased.

  A patient has been characterized as a CYP2D6 poor metabolizer (PM) after genotyping. Which of the following statements is not true?

  A. The patient will likely need lower doses of CYP2D6-metabolized drugs.

  B. The patient is less likely to require therapeutic drug monitoring (TDM) since the genotype is known.

  C. CYP2D6 metabolizes many drugs, and so attention must be given to the doses of drugs from different classes.

  Correct Answer: B

• Question 509:

  Streptococcus pyogenes is the correct answer. Streptococcus pneumoniae is alpha- hemolytic which demonstrate a green area of partial hemolysis around the colonies. Staphylococcus aureus will produce complete hemolysis but is catalase positive. Streptococcus agalactiae is beta-hemolytic but only produces a partial clearing of the red blood cells in sheep blood agar.

  Complete hemolysis of sheep blood agar as demonstrated by the image below would be seen in which of the following catalase-negative isolates?

  

  A. Streptococcus pneumoniae

  B. Streptococcus pyogenes

  C. Staphylococcus aureus

  D. Streptococcus agalactiae

  Correct Answer: B

• Question 510:

  The patient's BUN is within normal range (5-20 mg/dL) while the creatinine is about five times the upper normal range (0.6-1.2 mg/dL). Gross elevations in creatinine are almost always accompanied by elevations in BUN when there is kidney impairment. Either the BUN or creatinine value in this case is incorrect. Both tests should be repeated.

  A patient's BUN value is 15 mg/dl and his creatinine is 5 mg/dl. If this patient is not undergoing dialysis, what conclusion would you draw from these results?

  A. patient is normal

  B. patient is in early stage of renal disease

  C. patient protein intake is quite low

  D. patient has suffered muscle deterioration

  E. one of the values is in error

  Correct Answer: E