Exam Details

  • Exam Code
    :USMLE-STEP-3
  • Exam Name
    :United States Medical Licensing Step 3
  • Certification
    :USMLE Certifications
  • Vendor
    :USMLE
  • Total Questions
    :804 Q&As
  • Last Updated
    :Apr 12, 2025

USMLE USMLE Certifications USMLE-STEP-3 Questions & Answers

  • Question 401:

    A 9-year-old boy comes to the clinic for evaluation of a rash. The boy says that he began developing some blisters on his cheek the night prior. He says that over the past few days he has spent time outside with his friends "down by the creek." The rash appears to be a linear crop of vesicles beginning in front of his left ear and extending to the corner of his mouth. There is no erythema, and he describes them as quite pruritic. He has not had any fever, vomiting, or changes in his hearing

    Along with good skin hygiene, which of the following is the best treatment plan for this child?

    A. topical diphenhydramine for comfort

    B. oral diphenhydramine for pruritus

    C. topical and oral antibiotics which would cover Staphylococcus and Streptococcus

    D. topical high-potency fluorinated steroid

    E. oral acyclovir

  • Question 402:

    A 9-year-old boy comes to the clinic for evaluation of a rash. The boy says that he began developing some blisters on his cheek the night prior. He says that over the past few days he has spent time outside with his friends "down by the creek." The rash appears to be a linear crop of vesicles beginning in front of his left ear and extending to the corner of his mouth. There is no erythema, and he describes them as quite pruritic. He has not had any fever, vomiting, or changes in his hearing. What does this rash most likely represent?

    A. HSV infection of the facial nerve (Ramsey-Hunt syndrome)

    B. bullous impetigo

    C. allergic contact dermatitis (Rhus dermatitis)

    D. erythema chronica migrans

    E. cutaneous larval migrans

  • Question 403:

    Parents bring you a 9-month-old boy they recently have adopted from western Russia. They have sparse medical records of the child's past. They do know that the boy was the result of a sexual assault on the mother and was given up at birth. The child has been in a "baby home" for 5 months. The records which accompanied the boy indicate that there had been some testing done. These tests include HIV, hepatitis B and C serologies, and a rapid plasma reagin (RPR), all of which are negative at 8 months of age. There is what appears to be a Russian immunization record as well. It seems to indicate that the child has had three diphtheria, tetanus, pertussis (DTP), three oral polio, and three hepatitis B vaccinations. There is also an indication that BCG (Bacille Calmette-Guérin) was given.

    You place a purified protein derivative (PPD) and the parents come back in 48 hours to have it read. The response is 15 mm of induration. The boy does not have any respiratory symptoms at this time.

    What is the most appropriate response to this information?

    A. Collect three morning sputum and send for acid-fast stain and TB culture.

    B. Give a repeat BCG vaccine.

    C. Do nothing as the PPD is considered negative given the prior BCG vaccination.

    D. Perform a CXR and begin isoniazid (INH) for 9 months if the x-ray is negative.

    E. Perform a CXR and begin "triples" (INH, rifampin, pyrazinamide) even if the x-ray is negative.

  • Question 404:

    Parents bring you a 9-month-old boy they recently have adopted from western Russia. They have sparse medical records of the child's past. They do know that the boy was the result of a sexual assault on the mother and was given up at birth. The child has been in a "baby home" for 5 months. The records which accompanied the boy indicate that there had been some testing done. These tests include HIV, hepatitis B and C serologies, and a rapid plasma reagin (RPR), all of which are negative at 8 months of age. There is what appears to be a Russian immunization record as well. It seems to indicate that the child has had three diphtheria, tetanus, pertussis (DTP), three oral polio, and three hepatitis B vaccinations. There is also an indication that BCG (Bacille Calmette-Guérin) was given.

    The parents are concerned about fetal alcohol syndrome (FAS). Which physical feature is most consistent with FAS?

    A. smooth philtrum

    B. single palmar crease

    C. hypertelorism

    D. synophrys (confluent eye brows)

    E. low set ears

  • Question 405:

    Parents bring you a 9-month-old boy they recently have adopted from western Russia. They have sparse medical records of the child's past. They do know that the boy was the result of a sexual assault on the mother and was given up at birth. The child has been in a "baby home" for 5 months. The records which accompanied the boy indicate that there had been some testing done. These tests include HIV, hepatitis B and C serologies, and a rapid plasma reagin (RPR), all of which are negative at 8 months of age. There is what appears to be a Russian immunization record as well. It seems to indicate that the child has had three diphtheria, tetanus, pertussis (DTP), three oral polio, and three hepatitis B vaccinations. There is also an indication that BCG (Bacille Calmette-Guérin) was given.

    The parents are interested in having the boy tested for infections. What is the most appropriate evaluation at this time?

    A. No need to repeat the serologies because they have been done within the past month.

    B. Collect stool for ova and parasites only.

    C. Repeat all serologies (HIV, hepatitis B, hepatitis C, RPR) now.

    D. Perform a full sepsis workup (blood culture, urine culture, CSF culture).

    E. Screen for infections using CBC.

  • Question 406:

    A 41/2-year-old girl is brought to your office during summertime hours for ear pain. She has been swimming at camp for the past few days and now has copious cloudy discharge from her left external auditory canal with pain on movement of the pinna.

    What is the best course of treatment for this patient?

    A. amoxicillin PO

    B. erythromoycin PO

    C. erythromycin topical

    D. cefuroxime PO

    E. neomycin/polymyxin B/hydrocortisone topical

  • Question 407:

    A 41/2-year-old girl is brought to your office during summertime hours for ear pain. She has been swimming at camp for the past few days and now has copious cloudy discharge from her left external auditory canal with pain on movement of the pinna.

    What organism is the most common cause of this infection?

    A. methicillin-resistant Staphylococcus aureus (MRSA)

    B. S. pneumoniae

    C. Pseudomonas species

    D. nontypable H. influenzae

    E. GAS

  • Question 408:

    A 41/2-year-old girl is brought to your office during summertime hours for ear pain. She has been swimming at camp for the past few days and now has copious cloudy discharge from her left external auditory canal with pain on movement of the pinna.

    What is the most likely diagnosis?

    A. otitis media with perforation of the TM

    B. mastoiditis

    C. otitis externa (OE)

    D. foreign body in the ear canal

    E. tempero-mandibular joint dysfunction

  • Question 409:

    A 14-year-old boy is brought to the emergency department for evaluation of fever and headache. The mother relates that her son has had a worsening headache for 56 days. She says that she took him to a walk-in clinic, and he was put on amoxicillin for a sinus infection. His headaches have been getting worse and that he is now having fevers as high as 103.6°F . The mother says that he normally is very active and that he currently has a summer job at a local park clearing out underbrush. Since he has become ill, he has had such a decrease in energy that he cannot go to work. He has had a decrease in his appetite and has been sleeping more. He denies any sore throat, abdominal pain, chest pain, dysuria, vomiting, or diarrhea. On examination, he is an uncomfortable young man whose vital signs are: temp 101.9°F, RR 26, HR 124, and BP 79/56. is head, ear, eye, nose, and throat examination reveals normal TMs, a mildly erythematous hypopharynx, and some shotty cervical lymphadenopathy. His lungs are clear. His cardiac examination is normal. His liver edge is palpable just below the right costal margin and is mildly tender. His spleen is not palpable. His skin examination is normal with the exception of scattered petechiae around his ankles and wrists. A CBC reveals WBC 13,000 with 65% segs and 22% lymphs, hematocrit of 35, and platelet count of 95,000. His electrolytes reveal a Na 125, K 5.1, Cl 102, and bicarbonate 21. His BUN and Cr are normal.

    What additional testing would be warranted at this point?

    A. serum rickettsial titers

    B. ESR

    C. C-reactive protein (CRP)

    D. enteroviral polymerase chain reaction (PCR) on cerebrospinal fluid (CSF)

    E. head CT without contrast

  • Question 410:

    A 14-year-old boy is brought to the emergency department for evaluation of fever and headache. The mother relates that her son has had a worsening headache for 56 days. She says that she took him to a walk-in clinic, and he was put on amoxicillin for a sinus infection. His headaches have been getting worse and that he is now having fevers as high as 103.6°F . The mother says that he normally is very active and that he currently has a summer job at a local park clearing out underbrush. Since he has become ill, he has had such a decrease in energy that he cannot go to work. He has had a decrease in his appetite and has been sleeping more. He denies any sore throat, abdominal pain, chest pain, dysuria, vomiting, or diarrhea. On examination, he is an uncomfortable young man whose vital signs are: temp 101.9°F, RR 26, HR 124, and BP 79/56. is head, ear, eye, nose, and throat examination reveals normal TMs, a mildly erythematous hypopharynx, and some shotty cervical lymphadenopathy. His lungs are clear. His cardiac examination is normal. His liver edge is palpable just below the right costal margin and is mildly tender. His spleen is not palpable. His skin examination is normal with the exception of scattered petechiae around his ankles and wrists. A CBC reveals WBC 13,000 with 65% segs and 22% lymphs, hematocrit of 35, and platelet count of 95,000. His electrolytes reveal a Na 125, K 5.1, Cl 102, and bicarbonate 21. His BUN and Cr are normal.

    The best treatment course would include which of the following?

    A. continue amoxicillin only

    B. begin oral doxycycline

    C. add acyclovir to the amoxicillin

    D. begin oral corticosteroids E. stop all antimicrobials

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