Since cimetidine inhibits CYP2D6, less amphetamine will probably need to be given since it will not be able to be metabolized as readily.
Most drug interactions are like this: one drug inhibits or competes with the same CYP450 as another drug. The end result is that higher concentrations of one, or both, drugs are present, leading to potential toxicity.
A patient is taking cimetidine for a stomach ulcer. This drug inhibits CYP2D6. The patient is now prescribed amphetamine for narcolepsy. Amphetamine is metabolized by CYP2D6.
What would you predict?
A. The dose for the amphetamine needs to be lower than normal.
B. The dose for amphetamine needs to be higher than normal.
C. Nothing can be assumed until you know the patient's status (PM, EM, UM).
D. The two drugs can never be given together since they interact.
Escherichia coli and Klebsiella pneumoniae are two good quality control choices for the indole test. E. coli is indole positive, while K. pneumoniae is indole negative. A positive reaction is noted when there is a red layer at the top of the tube after the addition of Kov醕s reagent, while the negative result is a lack of color change in the top of the tube after the addition of Kov醕s reagent.
Which one of the following combinations of organisms would be appropriate positive and negative controls to verify the specific test functions listed?
A. Beta hemolysis - Escherichia coli and Streptococcus pyogenes
B. Catalase - Staphylococcus aureus and Staphylococcus epidermidis
C. Hydrogen sulfide production - proteus mirabilis and Salmonella typhi
D. Indole - Escherichia coli and Klebsiella pneumonia
E. Carbohydrate fermentation - Alcaligenes faecalis and Acinetobacter baumannii
The recommended order of draw for a complete blood count (CBC), prothrombin time, and cholesterol is:
A. light blue, red, and lavender
B. light blue, lavender, and red
C. red, lavender, and light blue
D. lavender, light blue, and red
Myoglobin release is strongly associated with muscle damage; therfore, it would most closely match a diagnosis of massive muscle trauma in this question. Myoglobinuria is MOST likely to be noted in urine specimens from patients with which of the following disorders?
A. hemolytic anemia
B. lower urinary tract infections
C. massive muscle trauma
D. paroxysmal nocturnal hemoglobinuria
FFP that has been thawed at 30 - 37oC and maintained at 1 - 6oC must be transfused within 24 hours. In contrast, "Thawed Plasma" can be used for up to 5 days as a replacement therapy for patients requiring stable clotting factors. Keep in
mind that these are two different component types and you are asked about FFP.
Blood Bank
FFP that has been thawed at 30 - 37oC and maintained at 1 - 6oC must be transfused within ___________ after it has been thawed.
A. 24 hours
B. 8 hours
C. 12 hours
D. 5 days
E. 10 days
Provide the equivalent measurement for 4 milligrams.
A. 7500 micrograms
B. 4,000 micrograms
C. 750 micrograms
D. 750,000
Unexplained bleeding is associated with immediate hemolytic transfusion reactions, but is not usually associated with delayed hemolytic transfusion reactions. The bleeding results from disseminated intravascular coagulation (DIC) due to ABO antibodies causing intraventricular hemorrhage (IVH).
Which of the following signs and symptoms may be associated with immediate transfusion reaction, but is NOT usually associated with delayed hemolytic transfusion reaction?
A. Fever and chills
B. Unexplained bleeding from surgical site
C. Unexplained drop in hemoglobin
D. Transient jaundice
Basophilic stippling is strongly associated with lead poisoning the lead toxicity can affect the bone marrow; causing this phenomenon.
Hematology
What is a prominent morphologic feature of lead poisoning:
A. Basophilic stippling
B. Hypersegmentation
C. Macrocytosis
D. Target cell
Gamma globulin (anti-D) is given to Rh-negative mothers to prevent any D antibody production, which could cause harmful effects in future pregnancies with an Rh-positive fetus. The administered anti-D will bind fetal Rh-positive cells that may come from the fetus in vivo; therefore the mother will not produce anti-D herself, preventing sensitization.
A solution of gamma globulins containing anti-Rh (D) is given to an Rh (D) negative mother to:
A. Prevent fetal cells from initially sensitizing the mother
B. Neutralize any of the child's antibody that may have passed the placental barrier
C. Neutralize any natural maternal antibodies present
D. Prevent greater antibody response in a previously sensitized mother
Once substance H is developed, the addition of the sugar N-acetylgalactosamine to the terminal position of the chain gives the molecule "A" antigenic activity. Which specific terminal sugar causes a red cell to have A antigenic activity?
A. Galactose plus glucose
B. Galactose
C. N-acetylgalactosamine
D. Glucose
Nowadays, the certification exams become more and more important and required by more and more enterprises when applying for a job. But how to prepare for the exam effectively? How to prepare for the exam in a short time with less efforts? How to get a ideal result and how to find the most reliable resources? Here on Vcedump.com, you will find all the answers. Vcedump.com provide not only ASCP exam questions, answers and explanations but also complete assistance on your exam preparation and certification application. If you are confused on your ASCP-MLT exam preparations and ASCP certification application, do not hesitate to visit our Vcedump.com to find your solutions here.