ASCP ASCP Certifications ASCP-MLT Questions & Answers

• Question 431:

  Platelet neutralization tests are one of the confirmatory tests that can be used to determine if a patient has a circulating lupus antibody, or lupus anticoagulant. The principle in this test involved the use of a freeze-thawed platelet suspension that, when mixed with the patient plasma, will neutralize the anti-phospholipid antibodies (lupus anticoagulant) present and allow for a corrected aPTT result upon re-testing. A patient has a history of repeated spontaneous abortion. Coagulation studies reveal an elevated APTT, normal PT, normal platelet function, and normal clotting time. Schistocytes were seen on the peripheral blood smear.

  Which test should be performed to determine if the patient has lupus anticoagulant?

  A. Factor VIII assay

  B. mixing studies with factor-deficient plasma

  C. antinuclear antibody test

  D. platelet neutralization test

  Correct Answer: D

• Question 432:

  The body compensates for alkalosis or acidosis of the blood PRIMARILY to regain a normal pH, between 7.35 - 7.45. When the body compensates for a respiratory or metabolic disorder, the MAIN goal is to achieve:

  A. correct carbonic acid level, since it is the most important system in the body

  B. a normal pH

  C. normal p02 and pCo2 for normal respiration

  D. correct bicarbonate level, since it is the most important system in the body

  Correct Answer: B

• Question 433:

  Bicarbonate and Chloride form an exchanger to help regulate and buffer the body's pH.

  The buffering capacity of blood is maintained by a reversible exchange process between bicarbonate and:

  A. Sodium

  B. Potassium

  C. Calcium

  D. Chloride

  Correct Answer: D

• Question 434:

  The A and B antigens are present on the red cells of an AB patient. H antigen is a precursor to the ABO antigens. An individual with type AB blood will demonstrate the complete absence of which of the following antigen sites?

  A. A

  B. B

  C. H

  D. None of the above

  Correct Answer: D

• Question 435:

  21 CFR 606.65 states, "Supplies and reagents shall be used in a manner consistent with instructions provided by the manufacturer."

  The correct answer is A. The reagents must be used according to the manufacturer's instructions for use. If the instructions say one or two drops may be used and the facility procedures also allow one or two drops, then there is no problem

  with the staff members choosing to use two drops.

  While equipment must be calibrated, it does not generally influence the number of drops used.

  Staff members often ask co-workers and colleagues from other facilities how to perform tasks, but it is the manufacturer's instructions for the operation of equipment and the use of reagents that must be followed.

  A laboratory employee who is performing an internal audit of routine ABO and Rh typing procedures notes that a technologist places two drops of Anti-D in a tube, centrifuges the tube for 20 seconds, and reads the reaction using a magnifying

  mirror. When questioned about the procedure, the technologist indicates that most staff use two drops of Anti-D reagent because the reactions are stronger with two drops. In addition to reviewing the facility procedure manual, what should be done to ensure regulatory compliance?

  A. Review the anti-D manufacturer's current instructions for use.

  B. Check the calibration records for the centrifuge.

  C. Call a colleague at another institution to ask what they do.

  Correct Answer: A

• Question 436:

  A key laboratory characteristic by which Mycobacterium bovis can be separated from Mycobacterium tuberculosis is:

  A. Niacin accumulation when grown on egg based medium

  B. Ability to take up iron salts from the culture medium

  C. Growth inhibition by thiopine-2-carboxylic acid hydrazide (T2H)

  D. Semiquantitative catalase

  Correct Answer: C

• Question 437:

  Mrs. Jones, a diabetic, is admitted to the hospital on November 25th. It appears that she has had an AMI but did not feel the severe chest pain because of diabetic neuropathy. She has not felt well since November 20th and her physician believes she possibly had an AMI on November 20th.

  Assuming that the infarct was uncomplicated, which of the following cardiac biomarkers would most likely still be elevated and would assist in an AMI diagnosis?

  A. Myoglobin

  B. Creatine kinase MB (CK-MB)

  C. Cardiac troponin I (cTnI) or cardiac troponin T (cTnT)

  Correct Answer: C

• Question 438:

  An automated method for measuring chloride which generates silver ions in the reaction is called:

  A. Coulometry

  B. Potentiometry

  C. Chromatography

  D. Polarography

  E. Densitometry

  Correct Answer: A

• Question 439:

  If Kappa or Lambda is predominant and CD5 is co-expressed with CD19 (CD19/CD5 dual positive lymphocyte population), and CD23 is expressed, chronic lymphocytic leukemia is a probable diagnosis. CD19 is normally found on normal B

  cell populations and CD5 is normally found on mature T cell populations. However, CD5 is present on B cells in B- chronic lymphocytic leukemia or Mantle Cell Lymphoma, both abnormal B cell malignant processes.

  CD23 expression is not consistent with Mantel cells as shown on the decision tree on the right.

  A monoclonal B-cell population (Kappa or Lambda predominant) with expression of CD19, CD20, CD23, and co-expression of CD5 is consistent with which of the following?

  A. A normal B cell

  B. Chronic lymphocytic leukemia

  C. Mantle cell lymphoma

  D. A mature T cell

  Correct Answer: B

• Question 440:

  The cell shown in this image is a myelocyte. Myelocytes typically have an eccentric nucleus with cytoplasm similar to a mature neutrophils with a slightly bluer tint due to the cell's immaturity.

  

  Myelocytes have both primary and secondary granules present in the cytoplasm. The nucleus is less mature and therefore has a loose chromatin clumping pattern. Identify the cell in this illustration indicated by the arrow:

  A. Myelocyte

  B. Monocyte

  C. Metamyelocyte

  D. Lymphocyte

  Correct Answer: A