Exam Details

  • Exam Code
    :USMLE-STEP-3
  • Exam Name
    :United States Medical Licensing Step 3
  • Certification
    :USMLE Certifications
  • Vendor
    :USMLE
  • Total Questions
    :804 Q&As
  • Last Updated
    :Apr 12, 2025

USMLE USMLE Certifications USMLE-STEP-3 Questions & Answers

  • Question 641:

    A74-year-old male with a history of hypertension, CAD, and a 50 pack-year history of smoking presents with complaints of pain and cramping sensation of the thigh and buttock areas for the past 2 months. On detailed history, patient reports that the pain is usually during ambulation and relieves with sitting down. The pain does not change with respect to sitting or supine position. He denies any recent trauma, weakness of the legs, or paresthesias. He takes his prescription medications regularly and denies using alcohol, drugs, or any herbs/ supplements. Which of the following should be performed as an initial test to help confirm your clinical impression?

    A. ankle-brachial index (ABI)

    B. x-ray of the lumbar spine

    C. electromyelography and nerve conduction studies of the lower extremities

    D. lower extremity venous ultrasound with Dopplers

    E. angiography of the aorta and lower extremities

  • Question 642:

    A 17-year-old male presents for evaluation of shortness of breath. He has episodes where he will audibly wheeze and have chest tightness. His symptoms worsen if he tries to exercise, especially when it is cold. He has used an OTC inhaler with good relief of his symptoms, but he finds that his symptoms are worsening. He now has episodes of wheezing on a daily basis and will have nighttime wheezing and coughing, on average, five or six times a month. You suspect a diagnosis of asthma.

    Which of the following is the most appropriate pharmacologic regimen for this patient?

    A. a systemic antihistamine as needed

    B. a short-acting inhaled bronchodilator as needed

    C. a scheduled inhaled steroid and a shortacting inhaled bronchodilator as needed

    D. a scheduled long-acting beta agonist, a scheduled inhaled steroid, and a shortacting inhaled bronchodilator as needed

    E. a systemic corticosteroid, a scheduled inhaled steroid, and a scheduled longacting beta agonist

  • Question 643:

    A 17-year-old male presents for evaluation of shortness of breath. He has episodes where he will audibly wheeze and have chest tightness. His symptoms worsen if he tries to exercise, especially when it is cold. He has used an OTC inhaler with good relief of his symptoms, but he finds that his symptoms are worsening. He now has episodes of wheezing on a daily basis and will have nighttime wheezing and coughing, on average, five or six times a month. You suspect a diagnosis of asthma.

    Your diagnostic workup confirms the diagnosis of asthma. What clinical classification of asthma does this patient have?

    A. exercise-induced asthma

    B. mild asthma

    C. mild persistent asthma

    D. moderate persistent asthma

    E. severe persistent asthma

  • Question 644:

    A 17-year-old male presents for evaluation of shortness of breath. He has episodes where he will audibly wheeze and have chest tightness. His symptoms worsen if he tries to exercise, especially when it is cold. He has used an OTC inhaler with good relief of his symptoms, but he finds that his symptoms are worsening. He now has episodes of wheezing on a daily basis and will have nighttime wheezing and coughing, on average, five or six times a month. You suspect a diagnosis of asthma. Which of the following would confirm your suspicion of the diagnosis of asthma?

    A. presence of expiratory wheezing on examination

    B. increase in FEV1 of 15% after giving inhaled albuterol

    C. a decreased serum IgE level

    D. presence of eosinophils on a sputum sample

    E. a peak expiratory flow measurement 30% below the predicted normal value for the patient

  • Question 645:

    A 64-year-old male has been suffering from lower back pain for over 10 years. You have been following him for this period. You have prescribed stretching exercises and, occasionally, an anti-inflammatory medication to alleviate his pain. Although he has had no neurologic deficits in the past, today he has shown up in your office unexpectedly, complaining of bilateral lower back pain with numbness and tingling over the dorsal aspect of both feet. His symptoms have become progressively worse over the past 2 weeks and he is now unable to stand for more than 5 minutes without developing extreme pain and numbness. His symptoms are much improved by sitting down or kneeling over a chair. Climbing stairs seems to be tolerated well, but walking greatly exacerbates the pain. He denies bladder or bowel incontinence or retention, point tenderness or anesthesia in the lower back along the spinal cord or in the saddle area.

    Which of the following imaging studies would be most helpful to confirm the diagnosis?

    A. an MRI of the lumbosacral spine

    B. an x-ray of the lumbosacral spine

    C. an indium-tagged WBC scan

    D. a bone scan of the sacrum

    E. nerve conduction study of the legs bilaterally

  • Question 646:

    A 64-year-old male has been suffering from lower back pain for over 10 years. You have been following him for this period. You have prescribed stretching exercises and, occasionally, an anti-inflammatory medication to alleviate his pain. Although he has had no neurologic deficits in the past, today he has shown up in your office unexpectedly, complaining of bilateral lower back pain with numbness and tingling over the dorsal aspect of both feet. His symptoms have become progressively worse over the past 2 weeks and he is now unable to stand for more than 5 minutes without developing extreme pain and numbness. His symptoms are much improved by sitting down or kneeling over a chair. Climbing stairs seems to be tolerated well, but walking greatly exacerbates the pain. He denies bladder or bowel incontinence or retention, point tenderness or anesthesia in the lower back along the spinal cord or in the saddle area.

    What is the likely diagnosis?

    A. spondyloathropathy of the sacroiliac joint

    B. age-related early degenerative joint disease (DJD) of the hips

    C. spinal stenosis of the lumbosacral area

    D. muscle spasm of the lower back

    E. cauda equina syndrom

  • Question 647:

    A 42-year-old woman with hyperlipidemia, hypertension, and hypothyroidism presents to your office for a routine follow-up visit. Her blood pressure is well controlled with hydrochlorothiazide. She has been on a stable dose of levothyroxine for 8 years and measurement of her TSH today is within normal limits. However, her LDL cholesterol level remains elevated despite taking a statin for the past 9 months and complying with lifestyle modifications. You decide that the addition of a low dose of cholestyramine would provide her with additional benefit. How would you advise the patient before beginning this therapy?

    A. She should take other medications at least 1 hour before or 4 hours after cholestyramine.

    B. She should take a multivitamin tablet daily.

    C. She should ingest the cholestyramine in its dry form.

    D. She may mix the cholestyramine with water, juices, or carbonated beverages.

    E. She should discontinue the cholestyramine immediately if she experiences steatorrhea.

  • Question 648:

    A 70-year-old male is seen in the office for chest pain. He reports that he is getting substernal chest pain, without radiation, when he mows his lawn. The pain resolves with 1015 minutes of rest. He has never had pain at rest. He has no other cardiac complaints and his review of systems is otherwise negative. He has an unremarkable medical history and takes only a baby aspirin a day. On examination, his blood pressure is 160/70, pulse 85, and respiratory rate 16. His cardiac examination is notable for a harsh, 3/6 systolic ejection murmur along the sternal border that radiates to the carotid arteries. His carotid pulsation is noted to rise slowly and is small and sustained. His lungs are clear. The remainder of his examination is normal.

    Subsequent workup confirms the diagnosis of critical aortic stenosis. Which of the following treatments would be most appropriate at this time?

    A. a beta-blocker

    B. an ACE inhibitor

    C. a long-acting nitrate with as-needed sublingual nitroglycerin

    D. balloon valvuloplasty

    E. aortic valve replacement

  • Question 649:

    A 70-year-old male is seen in the office for chest pain. He reports that he is getting substernal chest pain, without radiation, when he mows his lawn. The pain resolves with 1015 minutes of rest. He has never had pain at rest. He has no other cardiac complaints and his review of systems is otherwise negative. He has an unremarkable medical history and takes only a baby aspirin a day. On examination, his blood pressure is 160/70, pulse 85, and respiratory rate 16. His cardiac examination is notable for a harsh, 3/6 systolic ejection murmur along the sternal border that radiates to the carotid arteries. His carotid pulsation is noted to rise slowly and is small and sustained. His lungs are clear. The remainder of his examination is normal.

    Which of the following would be the most appropriate test to order next?

    A. echocardiogram

    B. exercise stress test

    C. cardiac catheterization

    D. 24-hour Holter monitor

    E. electrophysiologic studies

  • Question 650:

    A 70-year-old male is seen in the office for chest pain. He reports that he is getting substernal chest pain, without radiation, when he mows his lawn. The pain resolves with 1015 minutes of rest. He has never had pain at rest. He has no other cardiac complaints and his review of systems is otherwise negative. He has an unremarkable medical history and takes only a baby aspirin a day. On examination, his blood pressure is 160/70, pulse 85, and respiratory rate 16. His cardiac examination is notable for a harsh, 3/6 systolic ejection murmur along the sternal border that radiates to the carotid arteries. His carotid pulsation is noted to rise slowly and is small and sustained. His lungs are clear. The remainder of his examination is normal.

    Which of the following would be most likely to be seen on an ECG?

    A. S-T segment elevations in the precordial leads

    B. Q waves in the precordial leads

    C. low-voltage QRS complexes

    D. left ventricular hypertrophy pattern

    E. normal ECG

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